Steadfast Medishield

For ureic patients, it becomes necessary to provide all essential amino acids within the restricted protein intake. At times, it becomes a challenge therefore to combat this issue, Steadfast Medishield has launched a tablet by the name of aplazar. Aplazar contains all essential amino acids in the form of calcium salts. It comes with the benefits of aminos like isoleucine, leucine, phenylalanine, valine, methionine, lysine, threonine, tryptophan, histidine and tyrosine. The benefit of giving these amino is that they are formulated in a alpha ketoanalogue form. The benefit of giving alpha ketoanalogue form is that they do not put any extra load of nitrogen on the kidneys.

Aplazar also helps in maintaining nitrogen and calcium balance. They exert a favourable effect on calcium and phosphorus metabolism without inducing malnutrition. Also, alpha ketoanalogue forms slow down the progression of end stage renal disease (ESRD). They reduce urinary protein excretion. Medical management of a kidney patient having diabetes is also a challenge. Aplazar can contribute in managing the condition to some extent. Aplazar can be used to improve or correct diabetes associated metabolic disturbances in type 2 diabetes.

It enables a good glycemic control in type 1 diabetes mellitus as well. This medication also be used as a predialysis medicine. This is due to the reason that it prevents kidney disease from getting worse and delays the initiation of dialysis. Aplazar should preferably be given with meals and it should be given carefully or stopped if the person has phenylketonuria. Since aplazar contains aminos in calcium salts therefore it can also help manage hypocalcemia. But in case of hypercalcemia, this drug can either be stopped or dosage should be reduced. Depending upon the weight of the person, the dosage of aplazar should be prescribed. Generally four to eight tablets, three times per day is advisable. 

Steadfast Medishield who are specialists in kidney transplant drugs, have come up with another wonder drug by the name of Tacstead. This medicine is basically an immunosuppressant drug which is an essential component of kidney transplant drugs. Organ rejection is the biggest risk involved during liver and kidney transplants because of our body’s tendency to reject the foreign body. By giving such drugs to the patient, this tendency is reduced, instead it increases the chances of acceptability. This drug has been formulated in multiple compositions containing tacrolimus in 0.25 mg, 0.5 mg, 1 mg and 2 mg.

This is due to the fact that every patient has his/her own requirements depending upon the biochemical profiles. Steadfast Tacrolimus provides that flexibility to administer the drug in the required dosage. Some of the common signs observed during organ rejection are fever above 100 degrees, decreased urine output, blood in urine, weight gain and tenderness of new kidney. In such cases, an immediate contact to physician or transplant centre is recommended. At times, there may be signs of infections.

Cyclosporin is also very commonly used as an immunosuppressant drug but several studies have indicate that tacrolimus is more effective and therefore preferred by doctors. These immunosuppressant drugs basically act as calcineurin inhibitor which blocks the activity of calcineurin. This blocking assists in reducing the immune response of our body. Apart from renal and liver transplant, this medicine is also given in conditions like lupus. There are some common side effects observed when this medicine is given like mild to moderate hypertension. First dosage of tacstead can be given within 24 hours of transplantation but it should preferably be given till kidney function has recovered. Tacrolimus has shown to be toxic when used in excess amount therefore dosage should be carefully given to the patients after only expert supervision by nephrologists.

Immunomodulatory response of vitamin D has long been known and recognised. The  active form of vitamin D (1,25-dihydroxyvitamin D) has the potential role in normal human functioning of immunity. Many research analysis have played role in displaying the perspective of vitamin D and immunity. 

It is a key mediator of innate immune function. Both macrophages respond to 25-hydroxyvitamin D (25D), whcich is a vitamin D metabolite, 

It has been shown that there is a link between the normal functioning of the cells and the variations found in vitamin D status.

The T cells proliferation and with the over-arching effects being to suppress inflammation and promote antimicrobial responses .

Cholecalciferol , the active form of vitamin D is sent to many different areas of the body, which includes bones, intestines , lymphatic immune systems which have receptors to synthesise it. Coming to the immune system, T cells are known to accurately judge between invaders and self cells, thus preventing chances of having autoimmune disorders.

How to increase this fat soluble vitamin D intake? If your levels are below recommendations , then it is suggested to go for supplements. The dosage can be decided after discussing your diet and the amount of vitamin D3 supplementation needed. It is important to know that all fat soluble vitamins work synergistically together. It is important to have vitamin E and Vitamin A, through food sources or a multivitamin pill. Steadfast Medishield, which is an established company , provides supplementation of dosage of 60,000 IU Vitamin D 3 under the name Adferol. If you are supplementing with such dosage on your own, it is important to get your levels checked and take doctor’s advice on it.

It is very crucial to meet the protein requirements of kidney patients as there are many factors which needs to be considered. For instance, the stage of chronic kidney disease, whether there is any other pre existing medical concern, type and form of protein and the bioavailability to the body and the profile of amino acids it offers. A study mentioned in Indian journal of Nephrology shows the comparison effects of whey and egg protein or albumin supplementation in dialysis patients. In the study, fifty adults were randomised to receive either whey protein and the other group was given egg protein. The actual intake was calculated from dietary recall and assessment was made by BIA machine. Also, for confirmation even repeat analysis was done.

Only 34 out of 50 completed the study, as certain didn’t tolerate it quite well as they faced nausea , vomiting as a acute side effect. In hospitals, to avoid malnutrition use of whey protein supplements is suggested by clinical dieticians to keep up with their nutritional status. The impaired gastric secretion due to drugs interfere with proper digestion and gives rise to use of supplements which are easy to digest, fast absorption properties such as whey protein. 

Since the nutritional stats of such patients is also compromised due to side effects of drugs, suppression of appetite etc, the dietary supplements  which provides certain important vitamins and minerals as well is a more effective approach. More long term research studies needs to carry on the investigation and infer more facts related to oral supplementation , parenteral supplementation needs and protein ratio. Renuris formula provides whey in combination with nutrients.

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The elemental form of Nodosis tablet provides 5.9 mEq of sodium and bicarbonate in 500 mg of tablet, the other form nodosis Ds PROVIDES 1000 mg bicarbonate , the third form gives 11.9 mEq of sodium and bicarbonate in 15 ml of Nodosis suspension and the forth form gives 5.95 mEq in 500 mg of  NODOSIS-GST tablet. Each form has 20 blisters with 15 tablets in each blister and comes in a box. 

Acidosis can happen to anyone children, adults, elderly and at any age which is a side effect of certain chronic disorders. This happens if your body is making too much acid , too little base , not eliminating out acids as fast or well. Its effect can be mild to serious and life threatening. It has a direct affect on how your body functions and can certainly lead to other health problems.

Treatment certainly depends upon the cause. As this condition is due to changes that affect the kidneys, blood circulation or digestion. 

The common conditions are Diabetic ketoacidosis, poor kidney function, lactic acidosis, diarrhoea, ketogenic diet (foods that promote ketone bodies production). Other non disease related causes include alcohol or drug abuse. Drugs that slow down breathing like sleep medications, pain killers, certain narcotics. The third kind of acidosis called respiratory acidosis caused in conditions like asthma , chronic obstructive pulmonary diseases happens when lungs are not able to breath out carbon dioxide properly. As excessive CO2 production increases acidosis. 

Depending upon the cause of acidosis occurrence at the first place and severity , the treatment is given. For example for metabolic compensation use of  sodium bicarbonate orally or intravenously is done.

NODOSIS ( sodium bicarbonate tablet) is used to treat acidosis in kidney disease , also used as a alkalising agent in many conditions where acidosis occurs. Lets say conditions like in advanced cardiovascular life support (ACLS)  where CPR (cardiopulmanory resuscitation) is done, and in the treatment of certain intoxications for instance , methyl alcohol , salicylates to decrease renal 

Reabsorption of the drug .

Each coated film tablet contains coated sodium bicarbonate 500 mg, nodosis DS contains film coated sodium bicarbonate IP 1000 mg.  Another one, NODOSIS suspension is flavoured syrup base 1000 mg in 15 ml syrup and enteric carted sodium bicarbonate 500 mg in the form of NODOSIS-GST.

How does it help treat acidosis conditions?

NODOSIS therapy increases plasma bicarbonate by use of supplied sodium Bicarbonate, firstly, by buffering excess hydrogen ion concentration. Secondly, by raising blood pH and reverses the clinical consequences of acidosis. Generally, plasma concentration is regulated by the renal system or kidney through the action of acidification of the urine. Additionally, by alkalinization of the urine when there is an excess and bicarbonate anion is considered “labile at a proper concentration of hydrogen ion (H+) , it may get oxidised to carbonic acid (H2CO3) and to make it a volatile form, carbon dioxide (CO2) is excreted by the lungs. 

Normal ratio of 1:20 (carbonic acid: bicarbonate) is present in the extra cellular fluid. In a healthy adult with proper and normal kidney function, practically all the glomerular filtered bicarbonate ion gets reabsorbed an less than 1% is excreted in the urine.

Oxomagnesium is a form of magnesium salt which is generally used to treat low magnesium level in the body. There are so many compositions of magnesium salts are available in the Indian pharmaceutical market, like magnesium citrate, magnesium carbonate, magnesium chloride, magnesium lactate, magnesium aspartate, magnesium glycinate, magnesium gluconate, etc. The amount of Magnesium in the gastrointestinal system particularly in the digestive tract is the major factor that is responsible for control the amount of magnesium to be absorbed by the body. 

Magnesium Oxide is effectively absorbed and upgrades the biologically active levels of magnesium in the bloodstream. This form will not raise blood magnesium levels excessively, and therefore will not be quickly excreted through urine or faces. MgO contains a far greater amount of elemental magnesium than any other magnesium salt.

 Steadfast Medishield Magnesium oxide 400 mg tablet is the newest edition in the medicinal field, because of single dosages of magnesium oxide in a pocket-friendly manner is still limited. This is magnesium salt is in oxide form. Steadfast Medishield is one of the renowned pharmaceutical companies present in the Indian market. Many of their formulae are presented in the form of an oral tablet. The motto of the company is to provide the best nephrological medicines to the patients for their best treatment.Those formulas are also very cost-effective. All the formulation is made after long term research and always keeping the organ safety in mind. The pioneering formula of only Magnesium Oxide if can be used in many savior medical conditions like heart released diseases, kidney-related issues or even in muscular atrophy. 

The normal level of serum magnesium is 0.7- 1 mmol/L. If it falls under 0.7 mmol/L it is termed Hypomagnesemia. In general, these symptoms are misunderstood with other micronutrient deficiency, thus careful monitoring is essential. It can be prevented with the proper and timely dosage decided by the expert. 

Magnesium is a important part of many reactions that occur in the body, affecting our cellular function, nerve conduction, and other biochemical reactions involved for optimal regulation. Normal serum magnesium levels lie between 1.4 and 2.6 mg/dL.  Hypomagnesemia is an electrolyte imbalance , characterised by low level of blood serum magnesium (less than 1.4 mg/dL) and  can be due to many causes or factors.

For instance, Chronic disease, alcoholism, gastrointestinal losses, renal losses, and other conditions. It is important to know the root cause of the condition , as it is the prime step for the treatment to get started. 

This can happen by consulting a renal specialist,  in case you suspect an inherited tubular disorder or if you doubt due to any existing condition. Symptoms include anything from vomiting , tremors and weakness to cardiac ischemia, depending upon the severity of the condition. All the mentioned symptoms are due to lack of magnesium which enlightens us with the fact that how important it is to include mg sources of foods in our diets or to start with elemental mg supplements. 

In hospitalised conditions, treatment is based depending upon the patient’s kidney functioning rate, or blood dynamic stability. Furthermore, for a individual who is not severely deficient and in a position  to take oral supplements, oral replacement is preferred. After a period of time and under doctor’s advice the  serum electrolyte levels must be checked , to ensure whether the levels are getting back to normal or not.  Although, serum magnesium levels rise at a faster rate, but intracellular magnesium takes more time  to replenish back to normal. Oral supplements which are in magnesium oxide form are absorbed better as per certain research studies. Although, doctor’s consultation is needed before starting with any Mg supplement and one should try to consume foods which are good sources of Mg. 

Magnesium is one such mineral which at times get overlooked during medical management of certain diseases. It has been seen that approx. 60% of patients who are critically ill have low magnesium levels. Specifically talking about diseases like cancer, renal disorder and kidney transplantation; it has been observed that patients have significantly low magnesium levels. Since the symptoms of magnesium deficiency are almost similar of other nutrient deficiencies like potassium, calcium so at times it remain undetectable. During the treatment of renal disorders and kidney transplantation, immunosuppressants are given to the patients. It has been observed that these immunosuppressants results in low magnesium levels. The calcineurin inhibitors, cyclosporine A (CSA) and tacrolimus are some of the immunosuppressants given which can cause hypomagnesemia by suppressing reabsorption of magnesium (Mg) from renal tubules. Low magnesium levels can further progress renal impairment or it may lead to encephalopathy especially in patients receiving tacrolimus. Steadfast Medishield who are proficient and specialised in understanding the pharmaceutical needs of renal patients came up with this initiative by the name of Magmaxx. This is an oral magnesium oxide supplement which was launched especially keeping in mind the hypomagnesemia which is often a symptom in kidney patients. This tablet consists of 400 mg of magnesium oxide. The oxide form was chosen due to its high elemental content and slow excretion rate from our body. MgO contains greater amount of elemental Mg than any other magnesium salt with high absorption rate. Oral supplementation of magnesium is generally considered as safe and well-tolerated but some may report of nausea, vomiting, diarrhoea. Overdose of magnesium may lead to hypotension, muscle weakness, and coma hence it is always recommended the before consuming any magnesium supplement, always consult a physician or an expert.